DataSheet_1_Characterizing the supragingival microbiome of healthy pregnant women.pdf

The ecological characteristics and changes of the supragingival plaque microbial community during pregnancy are poorly understood. This study compared the microbial community characteristics of supragingival plaque in pregnant and non-pregnant women, with the aim of identifying specific microbial lineages and genera that may be associated with pregnancy. Thirty pregnant women were randomly selected from the First Affiliated Hospital of Xinjiang Medical University and divided into groups based on pregnancy trimester: first trimester (group P1, n=10, ≤12 weeks), second trimester (group P2, n=10, 13–27 weeks), and third trimester (group P3, n=10, 28–40 weeks). Ten healthy non-pregnant women (group N) were enrolled as the control group. Supragingival plaque samples of all subjects were collected and oral microbial composition was surveyed using a 16S rRNA gene sequencing approach. Statistical analysis was performed using a nonparametric test. The Chao 1 index of P3 was significantly lower compared with that of N, P1, and P2 (P

妊娠期间龈上菌斑微生物群落的生态特性和变化尚未得到充分认识。本研究旨在通过比较妊娠妇女和非妊娠妇女龈上菌斑的微生物群落特征，以识别可能与妊娠相关的特定微生物系和属。本研究从新疆医科大学第一附属医院随机选取了30名妊娠妇女，并根据妊娠期将其分为三组：妊娠早期组（P1组，n=10，≤12周）、妊娠中期组（P2组，n=10，13-27周）和妊娠晚期组（P3组，n=10，28-40周）。另外，纳入了10名健康非妊娠妇女（N组）作为对照组。收集了所有受试者的龈上菌斑样本，并采用16S rRNA基因测序方法对口腔微生物组成进行了调查。统计分析采用了非参数检验方法。与N组、P1组和P2组相比，P3组的Chao 1指数显著降低（P