IUCLID

A new IUCLID database is provided containing results from non-clinical animal studies and human information for 530 approved drugs. The database was developed by extracting data from pharmacological reviews of repeat-dose, carcinogenicity, developmental, and reproductive toxicity studies. In the database, observed and no-observed effects are linked to the respective effect levels, including information on severity/incidence and transiency/reversibility.本研究提供了一款全新的国际统一化学品信息数据库（IUCLID），该库收录了530种已获批药物的非临床动物实验结果与人体相关信息。本数据库通过提取重复给药、致癌性、发育毒性及生殖毒性研究的药理学综述数据构建而成。库内将观察到的效应与未观察到的效应分别与对应效应水平相关联，其中包含效应严重程度、发生率以及一过性与可逆性相关信息。