Mus musculus strain:C57BL6 Epigenomics. Mus musculus strain:C57BL6
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DNA methylation analysis of Th17 culture following AOA or R-2-HG treatment
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2017-01-04
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DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2]. DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2]
Epigenetic modifiers are promising targets to improve therapies in patients with cancer. Targeting the methyltransferase DOT1L with small molecule inhibitors has shown promising effects on the control
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The five significant canonical pathways related to changes in the methylation patterns for each tissues type.
The log (p-value) of each pathway was determined using Fisher’s exact test. The ratios were calculated as the number of input molecules mapped to a specific pathway divided by the total number of mole
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Additional file 8: of Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites
Table S6. Top enrichment results of age-associated differentially hypermethylated CpG positions (aDMPs) for age-related diseases and quantitative traits. (XLSX 12 kb)
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DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip
IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s
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Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.
Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated
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