Association of Indian gut microbiome with B-vitamin deficiency

A comprehensive national nutrition survey in Indian population (CNNS-2016-18) showeddeficiency of multiple essential micronutrients were still prevalent not only in vulnerablegroups but also in the general population (Hidden-hunger). Despite public health strategies inpast several decades, the prevalence of Hidden-hunger requires more innovativeinterventions.One of the integral sources of micronutrients for human has been the gut microbiota, knownto produce some of those essential micronutrients. However, behaviour of native gutmicrobiota in case of malnutrition has not been thoroughly investigated. So our hypothesis iswhether microbial dysbiosis (i.e, altered abundance and composition) contribute to theprevalence of deficiency of essential micronutrients?To address this gaps, we sequenced gut-metagenome of healthy and B6 and B12 deficient children from Balaghat district of Madhta Pradesh, India. Our analysis answerd if change in composition and dynamics of gut microbe(s) underlies micronutrient deficiency.