Selected patient characteristics of the included randomized trials.

NOAC: non-vitamin K oral anticoagulant. DVT: deep venous thrombosis. PE: pulmonary embolism. VTE: venous thromboembolism. OD: once daily. BID: twice daily. NA: not available†In contrast to the three other studies which used a single-drug approach for all treatment phases, the Hokusai-VTE used a traditional sequence of a heparin lead-in followed by an oral agent.‡In the Hokusai-VTE study the time in the therapeutic INR range was calculated excluding the initial heparin lead-in period and with correction for planned interruptions.Selected patient characteristics of the included randomized trials.