Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice

Perfluorooctanoic acid is a manufactured material extensively
utilized
in industrial and consumer products. As a persistent organic pollutant,
perfluorooctanoic acid has raised increasing public health concerns
recently. Although perfluorooctanoic acid is known to induce lipid
accumulation in the liver, the impact of perfluorooctanoic acid on
different lipid classes has not been fully evaluated. In this study,
we performed untargeted lipidomics analysis to investigate the impact
of perfluorooctanoic acid on the lipid homeostasis in C57BL/6 male
mice. Perfluorooctanoic acid disturbed the lipid profiles in serum
and liver, with a variety of lipid classes significantly altered.
Greater impacts were observed in the liver lipidome than the serum
lipidome. In particular, some lipid clusters in the liver were altered
by both high- and low-dose perfluorooctanoic acid exposure, including
the increase of unsaturated triglycerides and the decrease of sphingomyelins,
saturated phosphatidylcholines, saturated lysophosphatidylcholines,
and phospholipid ethers. In parallel with an increase in the liver,
a decrease of saturated phosphatidylcholines was found in the serum
of high-dose perfluorooctanoic acid-treated mice. The findings from
this study are helpful to improve the understanding of perfluorooctanoic
acid-induced dysregulation of lipid metabolism and perfluorooctanoic
acid-associated health effects in liver.