Cerebellar gene expression in Δα6-Cre Crfr1 knock-out mice. Mus musculus

Corticotropin-releasing factor (CRF) and its type 1 receptor (CRFR1) play an important role in the behavioral and neuroendocrine responses to stressful challenges, facilitating or down-playing specific functions dependent on the region and goal involved. Despite the well-established expression CRFR1 in granular cells (GrCs), the role of this system in procedural motor performance and memory formation remains elusive. To investigate the role of CRFR1 expression in cerebellar GrCs, we conducted mRNA-Seq in a mouse model specifically depleted of CRFR1 in these cells (Δα6-Cre Crfr1). Overall design: mRNA-Seq of 6 wild-type (WT) and 6 conditional knock-out (cKO) mouse cerebella.