Sulfur-Directed α‑C(sp<sup>3</sup>)–H Amidation of Pyrrolidines with Dioxazolones under Rhodium Catalysis
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Site-selective functionalization of saturated N-heterocycles such as pyrrolidines is a central topic in organic synthesis and drug discovery. We herein report the sulfur-assisted rhodium(III)-catalyzed sp3 C–H amidation of pyrrolidines with dioxazolones as amidating agents. The amenability of the thioamide directing group is elucidated by a series of control experiments.
创建时间：
2024-01-12
