S1 Table - Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

Table A. Demographic information for each cohort included the EOAD GWAS on individuals of European ancestry. Table B. eQTL datasets used in colocalization analyses. Table C. Genes within the LD block of the EOAD top SNP for each region resulting from the genetic covariance analyses. Table D. Results of MAGMA gene-based analysis for genes in loci showing genetic correlation between EOAD and lipid traits. Table E. Agora AD risk scores for genes in loci showing genetic correlation between EOAD and lipid traits. Table F. Results from MetaBrain meta-analysis of cis-eQTLs in the cortex of Europeans for loci showing genetic correlation between EOAD and lipid traits. Table G. Results from MetaBrain meta-analysis of cis-eQTLs in the hippocampus of Europeans for loci showing genetic correlation between EOAD and lipid traits. Table H. Max H4 values from eQTL colocalization analyses for genes in loci showing genetic correlation between EOAD and lipid traits. Table I. Variants with most signficant (minimum P-value) amyloid methylation for each gene in loci showing genetic correlation between EOAD and lipid traits. Table J. Variants with most signficant (minimum P-value) tau methylation for each gene in loci showing genetic correlation between EOAD and lipid traits. Table K. Results of single cell RNA sequencing analyses in Humans for genes in loci showing genetic correlation between EOAD and lipid traits. Table L. Results of single cell RNA sequencing analyses in zebrafish for genes in loci showing genetic correlation between EOAD and lipid traits. Table M. Z-scores and composite scores for all variables used to calculate the composite scores for genes in loci showing genetic correlation between EOAD and lipid traits. (XLSX)