Data_Sheet_1_Associations between special diet and incidence risk of osteoporosis: a Mendelian randomization study.docx

IntroductionOsteoporosis is a prevalent challenge in clinical orthopedics, affecting a significant percentage of individuals aged 50 and above. The goal of this study was to comprehensively understand the relationships between a specialized dietary regimen and the risk of developing osteoporosis.MethodsThis study employed extensive genome-wide association study (GWAS) summary statistics derived from the UK Biobank. It encompassed 8 kinds of special diets and 7 datasets pertaining to osteoporosis and associated symptoms. The principal analytical approach employed was the inverse-variance weighted method. Additionally, sensitivity analysis was employed to elucidate the diverse multiplicity patterns observed in the final model.ResultsOur results showed that there is significant evidence that a gluten-free diet is associated with osteoporosis [odds ratio (OR): 1.080, 95% confidence interval (CI): 1.048–1.112, p = 4.23E-07)]. Furthermore, there exists a suggestive link between the three distinct dietary approaches and osteoporosis [(OR: 0.949, 95%CI: 0.929–0.970, p = 3.00E-06) for comprehensive consumption; (OR: 1.053, 95%CI: 1.018–1.089, p = 2.23E-03) for abstaining from wheat consumption; (OR: 1.036, 95%CI: 1.005–1.068, p = 1.97E-02) for abstaining from sugar consumption]. No additional correlation between the special dietary regimens and osteoporosis has been observed.ConclusionOur research has uncovered a notable correlation between a gluten-free diet and the occurrence of osteoporosis. Furthermore, it exerts a promoting influence on the onset of osteoporosis, which stands in direct contradiction to the therapeutic principles for Celiac Disease’s complications. As such, a novel association among these three elements is postulated.

骨质疏松症在临床骨科中是一种普遍的挑战，影响着50岁及以上人群的显著比例。本研究旨在全面理解特殊膳食与骨质疏松症发生风险之间的关联。方法：本研究采用了来自英国生物样本库的广泛的全基因组关联研究（GWAS）汇总统计数据。涵盖了8种特殊饮食和7个与骨质疏松症及其相关症状相关的数据集。主要分析方法采用了逆方差加权法。此外，还进行了敏感性分析，以阐明最终模型中观察到的多种多重性模式。结果：我们的结果表明，有显著证据表明无麸质饮食与骨质疏松症相关[比值比（OR）：1.080，95%置信区间（CI）：1.048–1.112，p=4.23E-07]。此外，存在三种不同的饮食方法与骨质疏松症之间的暗示性联系[全面消费的比值比（OR）：0.949，95%CI：0.929–0.970，p=3.00E-06]；避免小麦消费的比值比（OR）：1.053，95%CI：1.018–1.089，p=2.23E-03）；避免糖消费的比值比（OR）：1.036，95%CI：1.005–1.068，p=1.97E-02]。未观察到特殊膳食与骨质疏松症之间存在其他相关性。结论：本研究揭示了无麸质饮食与骨质疏松症发生之间的显著相关性。此外，它对骨质疏松症的发生具有促进作用，这与治疗乳糜泻并发症的治疗原则直接相悖。因此，这三种元素之间存在着一种新的关联。