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AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

ChEBI2012-08-01 更新2026-07-21 收录

生殖细胞减数分裂

性染色体表观沉默

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-39652 数据链接链接失效反馈

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AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

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创建时间：

2012-08-01

生殖细胞减数分裂

精子发生

Male germ cell meiosis is essential for generating haploid spermatozoa in mice. Here, we investigate the essential role of DIS3 in male germ cell meiosis in mice. Conditional inactivation of DIS3 in s

NIAID Data Ecosystem60

HORMAD1 mutation disrupts synaptonemal complex formation and chromosomal segregation in fertilized eggs

生殖细胞减数分裂

染色体异常

Hormad1 encodes a protein that contains a HORMA domain, and unlike Mad2, Hormad1 expression is germ cell specific. We discovered that both male and female are infertile, and HORMAD1 has important func

NIAID Data Ecosystem30

Protein Arginine Methyltransferase 1 is Essential for the Meiosis of Male Germ Cells

生殖细胞减数分裂

基因功能转录组学

Methods: Prmt1 floxed mice were crossed with Rip2-Cre and Pdx1-CreERT2 mice to generate Prmt1 KO and Prmt1 iKO mice. R26-eYFP mice were crossed for lineage tracing experiments and cell sorting. All m

NIAID Data Ecosystem20

Single-cell RNA-seq of the developing C57BL/6 mouse ovary from E11.5 to E14.5. Single-cell RNA-seq of the developing C57BL/6 mouse ovary from E11.5 to E14.5

生殖细胞减数分裂

单细胞转录组学

We profiled a time-course single-cell RNA-seq on C57BL/6 mouse ovary from E11.5 to E14.5 to study the cell population heterogeneity and regulation of meiosis initiation. We collected single cell from

NIAID Data Ecosystem40

Mus musculus strain:Stra8-cre Raw sequence reads

生殖细胞减数分裂

RNA-seq差异表达分析

To identify differentially-expressed genes (DEG) in UHRF1-deficient spermatocytes that impair the progression of meiotic prophase, we performed RNA-seq for isolated spermatocytes from both Uhrf1_cKO a

NIAID Data Ecosystem20

AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

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