Assessing the role of TPL2 in TauP301S mice. Assessing the role of TPL2 in TauP301S mice
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA746341
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ScRNAseq analysis shows •TPL2 KD (kinase dead) reduced TauP301S dependent IEG and MHCII activation states in microglia •TPL2 KD reduced peripheral immune cell infiltration in TauP301S mouse brain Overall design: Single cell suspensions of mouse hippocampi were obtained by FACS from ~ 9-month-old TPL2 KD mice crossed with TauP301S mice and littermate control mice. Samples analyzed: 1. Tpl2 wt/wt, Tau P301S -/-, n = 3 2. Tpl2 kd/kd, Tau P301S -/-, n = 3 3. Tpl2 wt/wt, Tau P301S +/-, n = 6 4. Tpl2 kd/kd Tau P301S +/-, n = 6
创建时间：
2021-07-13
