Integrative ATAC-seq and RNA-seq Analyses of IPEC-J2 Cells Reveals Porcine Transcription and Chromatin Accessibility Changes Associated with Escherichia coli F18ac Inhibited by Lactobacillus reuteri

<em>Escherichia coli </em>(<em>E. coli</em>) is the main cause of postweaning diarrhea in pigs, leading to economic loss. As a probiotic, <em>Lactobacillus reuteri </em>(<em>L. reuteri</em>) has been used to inhibit<em> E. coli</em> in clinical applications; however, its integrative interactions with hosts remain unclear, especially in pigs. Here, we found that <em>L. reuteri</em> effectively inhibited <em>E. coli </em>F18ac adhering to porcine IPEC-J2 cells, and explored the genome-wide transcription and chromatin accessibility landscapes of IPEC-J2 cells by RNA-seq and ATAC-seq<em>.</em>