Loss of the nucleolar DUB USP36 impairs Parkin dependent mitophagy via downregulation of autophagic components
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https://www.ncbi.nlm.nih.gov/sra/SRP181143
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资源简介：
The Parkin dependent final elimination of defective mitochondria is halted by loss of the nucleolar DUB USP36. The authors suggest a general failure in autophagy induction due to a decline in Beclin-1 and ATG14 levels. Reduction of the epigenetic mark histone 2B lysine 120 ubiquitination possibly contributes to the observed phenotype. Overall design: comparison of mRNA expression levels from control siRNA and USP36 siRNA transient transfected HeLa cells of five independent experiments
创建时间：
2020-01-02
