HIV-1 Reservoir and Cellular Biomarker Data from Phase 2a Randomized Multisite Clinical Trial A5336 (NCT02475655)

Raw and absolute change from baseline (week 0) data set from A5336 human trial (NCT02475655) containing cellular biomarker expression as assessed via flow cytometry and HIV-1 reservoir quantification as assessed by Alu-LTR qPCR and intact proviral DNA assay (IPDA). Abbreviations: RUX (ruxolitinib arm (n=40)), CNT (control arm (n=20)), IPDA ++ (intact provirus only), IPDA +- (total provirus), IPDA -- (defective provirus only), N (naïve), CM (central memory), TM (transitional memory), EM (effector memory), and TD (terminally differentiated). High and Low reservoir stratification was based on week 0 Alu-LTR qPCR reservoir measurements, where the top tertile of each group was defined as high baseline reservoir and the bottom 2/3s were defined as low baseline reservoir.