Modulation of DNA Binding by Reversible Metal-Controlled Molecular Reorganizations of Scorpiand-like Ligands

DNA interaction with scorpiand azamacrocycles has been
achieved
through modulation of their binding affinities. Studies performed
with different experimental techniques provided evidence that pH or
metal-driven molecular reorganizations of these ligands regulate their
ability to interact with calf thymus DNA (ctDNA) through an intercalative
mode. Interestingly enough, metal-driven molecular reorganizations
serve to increase or decrease the biological activities of these compounds
significantly.