The LRF/ZBTB7A transcription factor is a BCL11A-independent repressor of fetal hemoglobin

ChEBI2016-01-15 更新2026-07-12 收录

血红蛋白调控

遗传性血液疾病靶点

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74977 数据链接链接失效反馈

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The LRF/ZBTB7A transcription factor is a BCL11A-independent repressor of fetal hemoglobin

创建时间：

2016-01-15

Transcription factor competition at the ?-globin promoters controls hemoglobin switching [ChIP-seq]

血红蛋白调控

转录因子竞争机制

BCL11A, the major regulator of HbF(a2?2) level, represses ?-globin expression through direct promoter binding in adult erythroid cells in a switch to adult adult-type HbA (a2Ã2) production. Yet, the

NIAID Data Ecosystem110

HIC2 represses BCL11A transcription to regulate hemoglobin switching during development (RNA-Seq). HIC2 represses BCL11A transcription to regulate hemoglobin switching during development (RNA-Seq)

血红蛋白调控

转录因子网络

The switch from fetal to adult hemoglobin production has been studied in great depth in part because of its relevance to the treatment of hemolobinopathies. Transcription factor BCL11A, which is essen

NIAID Data Ecosystem50

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation [RNA-Seq]

血红蛋白调控

RNA-Seq

While BCL11A protein is not well synthesized at these earlier stages of development, its mRNA curiously continues to be associated with ribosomes. Through unbiased proteomic analyses in erythroid cell

干细胞与再生医学数据中心2022-02-20 更新30

Transcription factor competition at the γ-globin promoters controls hemoglobin switching [CUT&RUN]

血红蛋白调控

转录因子竞争机制

BCL11A, the major regulator of HbF(α2γ2) level, represses γ-globin expression through direct promoter binding in adult erythroid cells in a switch to adult adult-type HbA (α2β2) production. Yet, the m

NIAID Data Ecosystem90

Investigation of Bach1 function by heme-iron homeostasis in bone marrow derived macrophage

巨噬细胞铁代谢

血红蛋白调控

Macrophages are central in regulating iron homeostasis. Transcription repressor Bach1 regulates by heme. Here we investigated the relationship between heme-regulated Bach1 and bone marrow derived macr

NIAID Data Ecosystem40

The LRF/ZBTB7A transcription factor is a BCL11A-independent repressor of fetal hemoglobin

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