Study on the data of Jianpi Yishentongqiao Granules treating allergic rhinitis based on network pharmacology and molecular docking

Allergic rhinitis (AR), also known as allergic rhinitis, is an infectious inflammatory reaction involving allergic reactions and inflammatory factors and immune cells in the body, mainly manifested by nasal congestion, runny nose, and itchy nose. AR is the most common allergic disease in the world, and its incidence has been on the rise in recent years. The number of patients worldwide accounts for about 10%-30% of the total population, which seriously affects the work and life of patients.
Jianpi Yishentongqiao Keli(JPYSTQKL) is the chief physician of the tutor Zhang Changxi engaged in clinical medicine for many years, accumulated a lot of experience in the treatment of AR, the Yupingfeng powder, Cangerzi powder, Erxian decoction added and reduced to cut.JPYSTQKL is composed of Aconitum carmichaelii Debeaux (Fuzi, FZ),Leonurus japonicusHoutt.(Chongweizi,CWZ),ministerial herbs Astragalus mongholicus Bunge (Huangqi, HQ), Epimedium sagittatum (Siebold & Zucc.) Maxim. (Yinyanghuo, YYH), Atractylodes macrocephala Koidz.(Baizhu,BZ),Gynochthodes officinalis (F.C.How) Razafim. & B.Bremer(Bajitian,BJT);the adjuvant herbs Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk.(Fangfeng,FF),Magnolia denudata Desr.(Xinyi,XY),Tabernaemontana divaricata (L.) R.Br. ex Roem. & Schult(Chantui,
CT),Perilla frutescens (L.) Britton(Zisu,ZS)and the messenger herbs Glycyrrhiza glabra L. (Zhigancao, GC), etc.With the use of cold and heat, warm tonifying and qi, so that the lung, spleen and kidney three viscera harmonization, a total of spleen and qi, tonifying kidney and Yang, wind clearing work. We investigated the possible effects of JPYSTQKL on AR through network pharmacology and in vivo experiments. In this paper, 30 key targets of JPYSTQKL, including JUN, IL6, TNF, AKT1, TP53, IL-1β, IL-4, CXCL8, and CCL2, were recorded through the MAPK signaling pathway, IL-17 signaling pathway, and TNF signaling pathway has therapeutic effect on AR rats.