Crystal Structure of LSD1 in complex with trans-2-pentafluorophenylcyclopropylamine
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Crystal Structure of LSD1 in complex with trans-2-pentafluorophenylcyclopropylamine Descriptor: Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-(pentafluorophenyl)-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate Authors: Mimasu, S, Umezawa, N, Sato, S, Higuchi, T, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2009-12-21 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1 Biochemistry, 49, 2010
创建时间：
2009-12-21
