Desarrollo de hidrogeles de colágeno cargados con nanopartículas de plata y aceite Cannabis sativa

Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the devel- opment of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

伤口代表了一个重大的医疗问题，尤其是在医院相关感染中，其中常涉及多重耐药菌株。如今，含有治疗分子的生物材料在伤口愈合和感染预防中发挥着积极作用。在本研究中，描述了负载银纳米颗粒和大麻籽油提取物的胶原蛋白水凝胶的开发。银纳米颗粒的存在赋予了生物材料如改善机械性能或抵抗胶原蛋白酶降解等有趣特性，而最重要的是其持久的抗菌效果。大麻籽油因其抗炎和镇痛作用而闻名，具有抗氧化活性，并成功提高了纳米复合材料的生物相容性，同时也增强了其抗菌活性。综合上述结果，表明这种新型纳米复合生物材料是伤口感染和伤口愈合传统治疗方法的有前景的替代品。