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An Asymmetric Synthesis of l-Pyrrolysine

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Figshare2016-02-21 更新2026-04-29 收录
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https://figshare.com/articles/dataset/An_Asymmetric_Synthesis_of_l_Pyrrolysine/2539636
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An efficient asymmetric synthesis of the 22nd amino acid l-pyrrolysine has been accomplished. The key stereogenic centers were installed by an asymmetric conjugate addition reaction. A Staudinger/aza-Wittig cyclization was used to form the acid-sensitive pyrroline ring. Pyrrolysine was synthesized in 13 steps in 20% overall yield.
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2016-02-21
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