NHLBI TOPMed: Diabetes Heart Study (DHS) African American Coronary Artery Calcification (AA CAC)

The Diabetes Heart Study (DHS) is a family-based study enriched for type 2 diabetes (T2D). The cohort included 1443 European American and African American participants from 564 families with multiple cases of type 2 diabetes (Bowden et al., 2010. Review of Diabetic Studies 7:188-201. PMID: 21409311). The cohort was recruited between 1998 and 2006. Participants were extensively phenotyped for measures of subclinical CVD and other known CVD risk factors. Primary outcomes were quantified burden of vascular calcified plaque in the coronary artery, carotid artery, and abdominal aorta all determined from non-contrast computed tomography scans.糖尿病心脏研究（Diabetes Heart Study, DHS）是一项基于家系的、富集2型糖尿病（type 2 diabetes, T2D）病例的队列研究。该队列纳入了来自564个存在多例2型糖尿病病例的家系的1443名欧裔美国人和非裔美国人受试者（Bowden等，2010，《糖尿病研究综述》（Review of Diabetic Studies），第7卷，第188-201页，PMID：21409311）。该队列的招募工作于1998年至2006年间完成。研究人员对所有受试者进行了全面的表型分型，以检测亚临床心血管疾病（subclinical Cardiovascular Disease, CVD）及其他已知心血管疾病风险因素。主要结局指标为通过非增强计算机断层扫描（computed tomography, CT）所测得的冠状动脉、颈动脉及腹主动脉的血管钙化斑块负荷。