Astrocytic changes in mitochondrial OXPHOS protein expression in Parkinson's disease

The astrocyte data uploaded includes the original dataset generated from imaging mass cytometry and its normalised z score data, alongside the area analysis data. The study has included a cohort of post-mortem human midbrain section from idiopathic PD cases (n=9) and individuals without neurological disease as controls (n=10). This dataset were used to investigate the expression change of mitochondrial OXPHOS proteins on Parkinson's astrocytes in the substantial nigra. The use of human tissue sections adhered to the Medical Research Council’s (MRC) guidelines on the use of human tissue in medical research. This work is currently under corrections with the journal, Movement Disorders.

本数据集包含由成像质谱光度计生成的原始数据集及其标准化z分数数据，以及面积分析数据。研究纳入了来自特发性帕金森病病例（n=9）的死后人类中脑切片，并将无神经疾病个体（n=10）作为对照组。该数据集被用于研究在黑质中帕金森病星形胶质细胞上线粒体氧化磷酸化蛋白表达的变化。使用人类组织切片遵循了医学研究理事会（MRC）关于在医学研究中使用人类组织的指导方针。目前，此项研究正在与《运动障碍》杂志进行校对。