Proposed pairs of human to rat orthologs with species specific pharmacology.

Reported are target pairs where observed differences in binding affinity deviate significantly from the control distribution. represents mean potency differences. Positive values of designate preferential binding to the human ortholog and negative values preferential binding to the rat ortholog. Asterisks mark values which are artifacts of faulty annotation. The number of tested compounds is reported in the column #cmpds and #chemotypes reports the number of chemotypes determined by hierarchical clustering.