Alignment of the OST-HTH/LOTUS domain in TDRD7 and Oskar.

Alignment of the conserved LOTUS domain shared by the TDRD7 and Oskar proteins from Pararge aegeria (Pa), Danaus plexippus (Dp), Bombyx mori (Bm), Drosophila melanogaster (Dm), Nasonia vitripennis (Nv), Apis mellifera (Am), Tribolium castaneum (Tc), Mus musculus (Mm) and Gryllus bimaculatus (Gb). Secondary structure annotation obtained from M. musculus structural data (PDB: 2LH9). Figure generated in ESPript 3.0 [57]. Columns with residues of similar physico-chemical properties (equivalent residue percentage) over 70% are in red with blue frames, strictly conserved positions highlighted red. The consensus sequence displays strictly conserved residues in uppercase while lowercase symbols indicate columns with a “MultAlin” similarity over 70% (IV / LM / FY / NDQEBZ). Exclamation mark refers to the amino acid I or V, “$”refers to the amino acid L or M, “%”refers to the amino acid F or Y, “#”refers to either the amino acid N, D, Q, E, B, or Z.