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Data for Radial arm maze tests and Novel object recognition test

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DataONE2022-12-20 更新2024-06-08 收录
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Background Aging population is rapidly expanding worldwide, and age-related cognitive impairments proves detrimental for achieving a better productive and quality of life. Lack of effective therapies for age-related cognitive impairment focuses attention on developing preventive strategies, such as nutritional interventions, cell therapies and environmental manipulations. The objective of present study was to explore the comparative benefits of potential memory-enhancing strategies like supplementation of choline and docosahexaenoic acid (DHA) or administration of conditioned media derived from human embryonic kidney stem cells (HEK-CM) or exposure to environmental enrichment (EE), that attenuates cognitive impairments in aging mice. Results Spatial memory and cognition were decreased in normal aging mice. Aged mice exposed to dietary Ch-DHA or HEK-CM showed significant enhancement in spatial learning tasks, memory and cognition compared to the same in age-matched NAC mice. Ch-DHA and ..., Eight-arm radial maze test The eight-arm radial maze is an elevated plexiform maze placed 80 cm above the floor. It consists of eight equally spaced arms [each arm is 42 cm long, 11.4 cm high, and 11.4 cm wide] radiating from an octagonal central platform and has a video monitor attached to a computer. Mice were allowed to familiarize themselves with the radial maze during the orientation /habituation phase. Before the test, mice were semi-starved for 48 hrs to reduce their body weight to 85% of the original body weight. During the orientation phase all the eight arms of the radial maze were baited with food pellets. Mice were allowed to orient and get habituated to the maze during two trials per day carried out for two days. Acquisition phase of a spatial task is conducted following habituation in the radial maze. During this phase, bait of food pellets was placed only in four arms of the radial maze. Before each trial and prior to each session, the maze was wiped with 50% alcohol to ..., DATA SET FILE DETAILS File 1. Percentage of correct choices made by mice during learning phase of eight arm radial maze test  File 2. Number of working memory errors made by mice during trial phase of eight arm radial maze test File 3. Number of reference memory errors made by mice during trial phase of eight arm radial maze test File 4. Percentage of correct choices made by mice during retention phase of eight arm radial maze test  File 5. Number of visits to familiar object made by mice during the test phase of novel object recognition test File 6. Number of visits to novel object made by mice during the test phase of novel object recognition test
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2023-11-29
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