Standard errors of the estimates of genetic correlations from published bivariate analyses of case-control studies for psychiatric diseases [7] vs. those predicted from the approximation theory.

SCZ: schizophrenia. BPD: bipolar disorder. MDD: major depression disorder. ASD: autism spectrum disorders. ADHD: attention-deficit/hyperactivity disorder. Ncases: number of cases. Ncontrols: number of controls. K: disease prevalence. : estimate of variance explained by all SNPs on the observed scale, which was calculated from the reported and disease prevalence in Supplementary Table 1 of Lee et al. [7]. : genetic correlation. SE(Obs.): reported standard error of the estimate of from real data analysis. SE(Approx.): standard error of calculated from our approximation theory.