PARN is essential to GSIS in beta cells

NIAID Data Ecosystem2026-05-02 收录

胰岛β细胞

基因功能机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE248559 数据链接链接失效反馈

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To investigated the function of PARN in beta cells, we generated the specific deletion of Parn in beta cells. Explore RNA directly bound by PARN

创建时间：

2024-11-21

Islet-specific microRNA changes driven by nutrient shift trigger postnatal beta-cell maturation - dispersed islet cell mRNAs after miR-17-5p transfection. Rattus norvegicus

胰岛β细胞

MicroRNA调控

We found that in rodents, postnatal beta-cell maturation is associated with changes in the expression of several islet microRNAs and discovered that these modifications are driven by changes in the nu

NIAID Data Ecosystem80

Supplementary Material for: The Placental Secretome: Identifying Potential Cross-Talk Between Placenta and Islet β-Cells

胎盘分泌组

胰岛β细胞

Background/Aims: Insulin-secreting islet β-cells adapt to the insulin resistance associated with pregnancy by increasing functional β-cell mass, but the placental signals involved in thi

DataCite Commons2025-05-01 更新50

Disturbance of lipid and glucose metabolism induce beta cell dedifferentiation in Ins-1 cell line

胰岛β细胞

糖尿病分子机制

In this study, we tried to clarify whether abnormal glucose and lipid metabolism can lead to beta cell dedifferentiation in vitro , and whether there is the role of transcription factor Foxo1 in this

NIAID Data Ecosystem30

RNA-seq to compare wild type, db/+ and db/db islets

胰岛β细胞

2型糖尿病转录组分析

Purpose: RNA seq analysis were to compare and contrast the gene expression profile involved in the dedifferentiation of db/db islets in type 2 diabetes Methods: Islets of wild type, db/+ and db/db wer

Alliance of Genome Resources60

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

胰岛β细胞

糖尿病分子机制

To gain insight into the history of islet cell deterioration along the progression from normal glycemic regulation to T2D, we collected surgical pancreatic tissue samples from 133 metabolically phenot

NIAID Data Ecosystem40

PARN is essential to GSIS in beta cells

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