Map of correlation analyses (bivariate non-parametric) between change in 1H-MRS metabolite concentrations during one-year versus levels of CSF markers at baseline and follow-up.

The magnitude of all correlation coefficients (r) are shown.**r>0.5;*r = 0.4–0.5;no asterisk rAbbreviations: tCr = total creatine; tNA = total N-acetylaspartate; mIns = myo-inositol; tCho = total choline; tGlx = glutamate + glutamine; Lac = lactate; NFL = neurofilament light protein; GFAP = glial fibrillary acidic protein; T-tau = total tauprotein; P-tau = phosphorylated tauprotein; MBP = myelin basic protein.