Whole-Cell Computational Model of Mycoplasma genitalium

The goal of this project was to develop the first detailed, "whole-cell" computational model of the entire life cycle of living organism, <i>Mycoplasma genitalium</i>. The model describes the dynamics of every molecule over the entire life cycle and accounts for the specific function of every annotated gene product. We anticipate that whole-cell models will be critical for synthetic biology and personalized medicine. Please see the project website <a href="http://wholecell.org">wholecell.org</a> and the Downloads page to explore the whole-cell knowledge base and simulations and obtain the model code. <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=714#pack_1169">M. genitalium whole-cell model </a> </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1671">Model-driven drug reposition.. </a> </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1389">Parameter est. DREAM Challenge </a> : Code for 2013 whole-cell model parameter estimation DREAM challenge </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1388">Synthetic networks </a> </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1290">WholeCellKB </a> </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1553">WholeCellSimDB </a> </li> <li> <a href="https://simtk.org/frs?group_id=714#pack_1307">WholeCellViz </a> </li> </ul>

本项目的宗旨在于构建首个全面而详尽的、针对生存生物体整个生命周期的全细胞计算模型，具体对象为支原体（Mycoplasma genitalium）。该模型详尽地描绘了生命全周期中每一个分子的动态变化，并对每个基因产物的特定功能进行了阐释。我们预判，全细胞模型在合成生物学与个性化医疗领域将发挥至关重要的作用。敬请访问项目网站（http://wholecell.org）以及下载页面，以探索全细胞知识库及模拟，并获取模型代码。此外，本项目还包括以下软件与数据包：

<ul>
<li><a href="https://simtk.org/frs?group_id=714#pack_1169">支原体全细胞模型</a></li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1671">模型驱动药物再定位</a></li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1389">参数估计 DREAM 挑战赛</a>：2013年全细胞模型参数估计 DREAM 挑战赛的代码</li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1388">合成网络</a></li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1290">WholeCellKB</a></li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1553">WholeCellSimDB</a></li>
<li><a href="https://simtk.org/frs?group_id=714#pack_1307">WholeCellViz</a></li>
</ul>