Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population leve
A compensatory increase in β-cell mass occurs during pregnancy to counter the associated insulin resistance, and a failure in adaptation is thought to contribute to gestational diabetes. Insulin-expre
The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell development, but its effects on adult β-cell function, survival, and proliferation are not well understoo
Adult (8-week-old; n = 5) and neonatal (2–3 days-old; n = 3) beta cells were cultured at the indicated glucose concentrations for 10 days with sequential labeling with EdU (day 3 to day 6) and BrdU (d
We have constructed a model to induce the proliferation of pancreatic beta cells by a short-term high-fat diet and attempted to explore the underlying mechanism by transcriptomics.