Administration of anti-IL-11 antibodies decreases neutrophil influx in the lungs of TB-infected mice*.

*Middle right lobes were individually isolated from two groups of mice (two independent experiments, exp. 1: N = 7 and 7; exp. 2: N = 9 and 10; total N = 16control and N = 17exp.), enzymatically disrupted, and single-cell suspensions analyzed by flow cytometry using FITC- or PE-labeled mAbs to the indicated surface markers. Results are presented as summarized mean ± SD for all animals.aFor F4/80+ macrophages and Ly-6G+ PMN: per cent of the total cell count; for B- and T-lymphocytes: per cent of the population gated for the lymphocyte size. Significant (Student's t-test) difference in the neutrophil content between experimental and control groups is highlighted in bold.bThe only statistically significant difference between mice that received control rabbit globulin and anti-IL-11 antibodies was a decrease in the lung neutrophil infiltration in the latter group.