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Preorganization in Highly Enantioselective Diaza-Cope Rearrangement Reaction

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NIAID Data Ecosystem2026-03-06 收录
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Crystal structure and activation entropy data indicate that H-bond directed diaza-Cope rearrangement of chiral diimines takes place with a high degree of preorganization. CD spectroscopy and HPLC data show that there is inversion of stereochemistry for the reaction with excellent enantioselectivity.

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2016-05-05
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