Clinical Response and Remission Results for the 36-Week Maintenance Period.

aSustained response was defined as a decrease in CDAI score from baseline (last non missing value before the first dose in the Induction period) ≥70 at Week 16 and no loss of the response during the 36-week Maintenance period. Loss of clinical response was defined as a CDAI score increase at any visit after the Week 16 visit of ≥70 from the Week 16 value and an absolute CDAI value of >250, or the need for intervention after Week 16. Missing values were also imputed as loss of response.
bSustained remission was defined as a CDAI score ≤150 at Week 16 and Week 52 and all visits in between. If data from any time point between Week 16 and 62 were missing for a subject, sustained remission was not achieved.
cn (%) = number and percentage of subjects in each group; % calculated as n/N x 100.
*p = 0.012; p-value was obtained from Mantel-Haenszel test, stratified according to geographic region, comparing the CCX282-B group with the placebo group.