Individual data for patients with reappearance of Plasmodium falciparum parasites during follow-up and median (IQR) values for cured subjects in the three dosing arms.

Key. Cmax = maximum plasma concentration (nM); AUC = area under the plasma concentration – time curve (h.nM); FCT = fever clearance time; PCT = parasite clearance time; Cured = subjects not meeting a parasitological endpoint (ETF, LTF) and completing 42 days follow-up; NI = new infection by PCR correction; R = recrudescent infection by PCR correction; PV = vivax parasitemia on blood smear requiring chloroquine treatment; VLTF = very late (>42d) treatment failure;*LTF not included in per protocol analysis as subject had already met an endpoint on Day 3 (ETF);**not included in per protocol analysis because recrudescence occurred after Day 42.