Identification of two subsets of murine Kupffer cells

Tissue macrophages are immune cells whose phenotypes and functions are dictated by their origins and tissue niche. However, tissues are complex environments and macrophage heterogeneity within a same organ has been largely overlooked so far. Here, we used high-dimensional single cell sequencing to characterize macrophage populations in the murine liver. We identified two distinct populations of Kupffer cells (KCs). Overall design: Examination of inherent murine Kupffer cell population heterogeneity