PSIP1/LEDGF reduces R-loops at transcription sites and maintain genome integrity

NIAID Data Ecosystem2026-05-01 收录

基因组稳定性

R-loop调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE220234 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-01-18

Histone H3.3 maintains genome integrity during mammalian development

表观遗传调控

基因组稳定性

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans, and has been implicated in many important biological processes including cell differentiation and reprogramming. Germlin

NIAID Data Ecosystem80

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats

R-loop调控

染色质重塑

ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)n. Acquired mutations in ATRX are found in nearly all tumours which maintain the

NIAID Data Ecosystem50

Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and Orientation

基因组稳定性

DNA修复

Repetitive DNA elements frequently are precursors to chromosomal deletions in prokaryotes and lower eukaryotes. However, little is known about the relationship between repeated sequences and deletion

PubMed Central30

SIRT7 tethering of L1 elements to the nuclear lamina mediates their transcriptional repression

基因组稳定性

表观遗传调控

Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of selfpropagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how

干细胞与再生医学数据中心2022-02-20 更新70

BLM prevents instability of structure-forming DNA sequences at common fragile sites

基因组稳定性

DNA修复

Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well

Figshare2018-12-11 更新50

PSIP1/LEDGF reduces R-loops at transcription sites and maintain genome integrity

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