Data from: Analytical performance, agreement and user-friendliness of six point of care testing urine analysers for urinary tract infection in general practice.

Objective: Various point-of-care testing (POCT) urine analysers are
commercially available for routine urine analysis in general practice. The
present study compares analytical performance, agreement and
user-friendliness of six different POCT urine analysers for diagnosing
urinary tract infection in general practice. Setting: All testing
procedures were performed at a diagnostic centre for primary care in the
Netherlands. Urine samples were collected at four general practices.
Primary and secondary outcome measures: Analytical performance and
agreement of the POCT analysers regarding nitrite, leucocytes and
erythrocytes, with the laboratory reference standard, was the primary
outcome measure, and analysed by calculating sensitivity, specificity,
positive and negative predictive value, and Cohen's κ coefficient for
agreement. Secondary outcome measures were the user-friendliness of the
POCT analysers, in addition to other characteristics of the analysers.
Results: The following six POCT analysers were evaluated: Uryxxon Relax
(Macherey Nagel), Urisys 1100 (Roche), Clinitek Status (Siemens), Aution
11 (Menarini), Aution Micro (Menarini) and Urilyzer (Analyticon).
Analytical performance was good for all analysers. Compared with
laboratory reference standards, overall agreement was good, but differed
per parameter and per analyser. Concerning the nitrite test, the most
important test for clinical practice, all but one showed perfect agreement
with the laboratory standard. For leucocytes and erythrocytes specificity
was high, but sensitivity was considerably lower. Agreement for leucocytes
varied between good to very good, and for the erythrocyte test between
fair and good. First-time users indicated that the analysers were easy to
use. They expected higher productivity and accuracy when using these
analysers in daily practice. Conclusions: The overall performance and
user-friendliness of all six commercially available POCT urine analysers
was sufficient to justify routine use in suspected urinary tract
infections in general practice.