X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001 Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]carbamate, 1,2-ETHANEDIOL, Protease Authors: Bulut, H, Hayashi, H, Hattori, S.I, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. Deposit date: 2018-09-02 Release date: 2019-04-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants. Antimicrob.Agents Chemother., 63, 2019
创建时间：
2018-09-02
