A New Class of Substituted Aryl Bis(oxazoline) Ligands for Highly Enantioselective Copper-Catalyzed Asymmetric Aldol Addition of Dienolsilane to Pyruvate and Glyoxylate Esters
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https://figshare.com/articles/dataset/A_New_Class_of_Substituted_Aryl_Bis_oxazoline_Ligands_for_Highly_Enantioselective_Copper_Catalyzed_Asymmetric_Aldol_Addition_of_Dienolsilane_to_Pyruvate_and_Glyoxylate_Esters/3318739
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资源简介：
A new class of bis(oxazoline) ligands are introduced that feature o-alkoxyaryl substituents and provide the highest enantioselectivities yet
reported for the copper-catalyzed asymmetric dienosilane aldol addition to pyruvate and glyoxylate esters. Enantioselectivities up to 98% ee
(before recrystallization) and isolated yields up to 91% were observed. Additionally, chloride counterions were found to be superior to triflate
for this reaction.
创建时间：
2016-05-06
