Senolytic treatment in osteoarthritis

NIAID Data Ecosystem2026-05-10 收录

衰老细胞清除

骨关节炎模型

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP622160 数据链接链接失效反馈

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资源简介：

This project investigates the effects of senolytic compound SSK1 on osteoarthritis progression using ACLT-induced models and primary human chondrocytes.

创建时间：

2025-09-21

Whole-Body Senescent Cell Clearance Alleviates Age-Related Brain Inflammation and Cognitive Impairment in Mice

衰老细胞清除

认知功能改善评估

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related

干细胞与再生医学数据中心2022-02-20 更新130

CAR T cells targeting uPAR are effective senolytics

CAR-NKT细胞疗法

衰老细胞清除

Cellular senescence is a stress-response program characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment. Physiologically, senescence serves as a

NIAID Data Ecosystem60

Real time PCR results for selected genes showing fold change in DMM joints relative to sham controls.

基因表达分析

骨关节炎模型

Real time PCR results for selected genes showing fold change in DMM joints relative to sham controls.

Figshare2015-12-02 更新50

CAR T cells targeting uPAR are effective senolytics

CAR-NKT细胞疗法

衰老细胞清除

Cellular senescence is a stress-response program characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment. Physiologically, senescence serves as a

NIAID Data Ecosystem60

Monosodium urate (MSU) crystals induced accumulation of inflammatory cytokines and cells into synovial joint mimicking subcutaneous air-pouch in the mouse.

骨关节炎模型

炎症因子分析

The amounts of accumulated cells and of proinflammatory cytokines monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), interleukin-1β (IL-1β), myeloperoxidase (MPO), macrophage inflammatory p

NIAID Data Ecosystem50

Senolytic treatment in osteoarthritis

资源简介：

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