Single-chain glucocorticoid-induced tumor necrosis factor receptor (GITR) agonist proteins

Provided herein are specific GITR receptor agonist proteins， nucleic acids encoding the same， and methods of treating a subject having a GITRL-associated disease or disorder. The GITR receptor agonist proteins provided herein comprise three soluble GITRL domains and an Fc fragment. The GITR receptor agonist proteins are substantially non-aggregating and suitable for therapeutic， diagnostic and/or research applications.