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Chromatin plays roles in processes governed by different time scales
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Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair
Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood. Her
DataCite Commons2020-08-26 更新80
High resolution chromatin dynamics during a yeast stress response
Covalent histone modifications are highly conserved and play multiple roles in eukaryotic transcription regulation. Because of extensive crosstalk between transcriptional processes and histone modific
NIAID Data Ecosystem70
MNase titration reveals differences between nucleosome occupancy and chromatin accessibility. MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
Chromatin accessibility plays a fundamental role in gene regulation. One mechanism to regulate accessibility is nucleosome placement, which is often measured by quantifying protection of DNA from enzy
NIAID Data Ecosystem50
Nucleosome occupancy as a novel chromatin parameter for replication origin functions
This study defines nucleosome occupancy as a novel parameter for regulating origin activities. Nucleosome occupancy at origins was assessed using histone H3 ChIP-seq during G1 and G2M. Origin activity
NIAID Data Ecosystem70
Nucleosome occupancy changes in mammalian cell differentiation and reprogramming (microarray)
Embryonic stem cells (ESCs) and induced-pluripotent stem cells (iPSCs) self-renew and differentiate into an array of cell types in vitro and in vivo. A complex network of genetic and epigenetic pathwa
NIAID Data Ecosystem50
