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The PAXX and XLF DNA Repair Factors are Functionally Redundant in Joining DNA breaks in a G1-arrested Progenitor B Cell Line

ChEBI2016-08-19 更新2026-07-12 收录

DNA损伤修复机制

B细胞发育

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-84102 数据链接链接失效反馈

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The PAXX and XLF DNA Repair Factors are Functionally Redundant in Joining DNA breaks in a G1-arrested Progenitor B Cell Line

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创建时间：

2016-08-19

B细胞发育

信号转导分析

We examined the global gene expression profile of PLCγ1/PLCγ2 double-deficient CLPsand B cell progenitors by RNA-seq analysis. Overall design: CLPs (Lin-IL-7R+) and B cell progenitors (B220+IgM-IL-7R+

NIAID Data Ecosystem100

The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement

B细胞发育

剪接体功能

The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and

NIAID Data Ecosystem60

Roles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli. Escherichia coli

DNA损伤修复机制

转录偶联修复

Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously pro

NIAID Data Ecosystem50

FAN1 R507H-PCNA-DNA_minimum-dataset

DNA损伤修复机制

冷冻电镜结构解析

This minimum cryo-EM dataset is used in the research of 'Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair'.

Figshare2025-02-10 更新70

Single Nucleotide Resolution Analysis of Nucleotide Excision Repair of Ribosomal DNA in Humans and Mice. Single Nucleotide Resolution Analysis of Nucleotide Excision Repair of Ribosomal DNA in Humans and Mice

DNA损伤修复机制

单核苷酸分辨率基因组学

In the present work we have applied analytical methods to map repair events in rDNA using data generated by the newly developed XR-seq genome-wide single nucleotide repair technology. We find that in

NIAID Data Ecosystem60

The PAXX and XLF DNA Repair Factors are Functionally Redundant in Joining DNA breaks in a G1-arrested Progenitor B Cell Line

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