Schistosoma mansoni strain:NMRI Raw sequence reads. Schistosoma mansoni strain:NMRI

Schistosomes are parasitic flatworms responsible for schistosomiasis, a neglected tropical disease (NTD) affecting 230 million and putting 700 million at risk. Penetration of the skin, migration through tissues and establishment of long-lived intravascular partners require Schistosoma to successfully manipulate definitive host defenses. Previous studies of larva schistosomula have postulated a function for protein excreted/secreted products in initiating these host-modulatory events, the role of extracellular vesicles (EVs) and small non-coding RNA (scnRNA) has yet to be considered. Using preparatory ultracentrifugation and sncRNA-seq analysis, we conducted the first characterization of Schistosoma mansoni schistosomula EVs and their potential host-modulatory cargos.