Schematic table of study design, experimental groups and investigations.

M, Male; F, Female; N, naïve rats separated from the dam for a period equivalent to the surgery time in the L group at P1; L, animals simply subjected to cortical freeze lesion at P1; HS, only exposed to hyperthermia-induced febrile seizures at P10; LHS, submitted to the combination of cortical freeze lesion at P1 and hyperthermia seizures at P10; L+T, subjected to perinatal testosterone administration (from E16 to P9) and cortical freeze lesion at P1; LHS+T, perinatal testosterone treatment plus dual postnatal insults at P1 and P10.