Understanding the variability of the peanut-oral immunotherapy response through multi-omics profiling of immune cells

Background: Oral immunotherapy is a promising treatment for peanut allergy inducing desensitization in most patients. However, 15-30% of patients do not respond, and a significant risk of anaphylaxis due to treatment remains.
Objective: This study aims to identify molecular differences between strong and weak treatment responders by investigating a comprehensive spectrum of omics profiles in immune cells.
Methods: We analysed immunoglobulins, cytokines, transcriptome and DNA methylome profiles in both peanut-stimulated and unstimulated immune cells isolated from 38 peanut-allergic children before and after oral immunotherapy.
Results: Our study identified 184 differentially expressed genes and 1001 differentially methylated genes associated with the strength of the oral immunotherapy response. Transcriptome and methylome profiling highlighted gut-resident innate (ILC3) and adaptive (CD8αα subset of CD8+ T cells) immune cells as essential players. Functional enrichment analyses additiona..., , , # Understanding the variability of the peanut-oral immunotherapy response through multi-omics profiling of immune cells

## Overview

This dataset accompanies the research paper by Arnau-Soler et al., titled \"Understanding the variability of the peanut-oral immunotherapy response through multi-omics profiling of immune cells.

## Contents

The dataset includes the following supplementary tables:

**Table E1.** Differentially expressed genes (DEGs) from all OIT samples (before and after OIT)

**Table E2.** Differentially expressed genes (DGEs) detected before OIT

**Table E4.** Differentially methylated probes (DMPs) associated with the peanut OIT response detected from all OIT samples (before and after OIT)

**Table E6.** Differentially methylated probes (DMPs) associated with the peanut OIT response detected before OIT

## Citing This Dataset

When using this dataset, please cite the original research paper:

Arnau-Soler et al., \"Understanding the variability of the peanut-oral immunot...