Acetate - XXL_VLDL_TG

This file contains the rare variant association summary statistics for the 313 metabolic traits profiled in an NMR-based metabolomics study involving 197,774 unrelated white British individuals from the UK Biobank.Metabolite data were processed to exclude values that deviated by more than four times the interquartile range from the median. Exome-wide gene-based collapsing analyses were then performed using Regenie (version 3.4). ACAT-O tests, SKAT-O tests, and burden tests were used, with age, ethnicity, sex, fasting time, month of assessment, assessment center, the top 10 genotype PCs being adjusted. Ten models were included to qualify variant criteria, which vary in terms of MAF (< 5e-6, < 1e-5, < 1e-4, < 0.001, and < 0.01), and predicted consequence (loss of function [LOF], LOF and likely deleterious missense). All performed tests were two-sided and the statistical significance threshold was determined to be 8.17 × 10−9 by using a Bonferroni correction for 313 traits and 19,559 protein-coding genes.