Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes. Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

The goal of this study was to compare the transcriptional profile (RNAseq) of dendritic cell (DC) subsets (XCR1+and CD11b+) with immunosuppressive activity recovered from the nasal associated lymphoid tissue (NALTs) to matched subsets with immunostimulatory activity recovered from the cervical lymph node. Overall design: 12 samples were analyzed: 3 replicates of CD11b+ DCs isolated from the cervical lymph node of naïve C57BL/6 mice. 3 replicates of XCR1+ DCs isolated from the cervical lymph node of naïve C57BL/6 mice. 3 replicates of CD11b+ DCs isolated from the NALTs of naïve C57BL/6 mice. 3 replicates of XCR1+ DCs isolated from the NALTs of naïve C57BL/6 mice