Transcriptomic profiling of inflammatory phenotypes of severe asthma using endobronchial biopsies

Severe asthma is a complex disease with different inflammatory phenotypes. Transcriptomic profiling has contributed to understanding the pathogenesis of asthma, especially type-2 inflammation; however, there is still poor understanding of non-eosinophilic asthma, and consequently there are limited treatment options. The aim of this study was to determine transcriptomic profiles in endobronchial biopsies of adults with severe asthma and different inflammatory phenotypes (neutrophilic, eosinophilic and paucigranulocytic) compared with healthy controls. This cross-sectional study examined endobronchial biopsies from 47 adults with severe asthma and different inflammatory phenotypes; neutrophilic (n = 9), eosinophilic (n = 22) and paucigranulocytic (n = 16) and healthy controls (n=13).